Longitudinal PACC Analyses

Significant Results Table

Summary table of all significant results (after fdr correction) from the following longitudinal PACC analyses:

1. PACC ~ GeneExp
2. PACC ~ GeneExp*Sex
3. PACC ~ GeneExp*E4
4. PACC ~ GeneExp*Sex*E4
5. PACC ~ GeneExp*Ab
6. PACC ~ GeneExp*Ab*Sex
7. PACC ~ Gene*p-tau

Analyses

All models are adjusted for sex, baseline age, years of education, cohort/treatment (A4 Placebo, A4 Treated, LEARN/SF), PACC story version, and cumulative dose. PACC story version and cumulative dose are time varying variables.

PACC ~ Gene x Sex x APOEe4

There is 1 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

ENSG00000211745

PACC ~ Gene x Amyloid

There are 6 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

Plots of select significant genes

ENSG00000115942

ENSG00000240132

PACC ~ Gene x Sex x Amyloid

There are 118 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

Plots of select significant genes

ENSG00000176371

ENSG00000163082

PACC ~ Gene x p-tau

There are 17 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

ENSG00000278434

ENSG00000225981